1992. initial submission: letter from allied-signal inc to usepa submitting information on 1,1,1,2-tetrafluoroethane 2-year inhalation toxicity/carcinogenicty study in rats It can also be used as a solvent in organic chemistry, both in liquid and supercritical fluid. 1 Toxic Effects and Mode of Action 1,1,1,2‐Tetrafluoroethane (tetrafluoroethane) is absorbed rapidly from the inhaled air and distributed relatively evenly in the organism. A reduction in maternal body weight gain in rabbits exposed to 40 000 ppm (166 800 mg/m 3) 1,1,1,2-tetrafluoroethane and signs of delayed fetal development in rats following exposure of the dams to 50 000 ppm (208 500 mg/m 3) 1,1, 1,2-tetrafluoroethane have been noted in developmental toxicity studies. 1,1,1,2-Tetrafluorethan 1,1,1,2-Tetrafluoroethane 1,2,2,2-Tetrafluoroethane Arcton 134a CCRIS 7214 EINECS 212-377-0 F 134a FC 134a Fron 134a HCFC 134a HFA 134a HFC 134a HSDB 6756 Khladon 134a Norflurane Norflurano [INN-Spanish] Norfluranum [INN-Latin] R … (1995). Toxicity AEL* (8- and 12-hr TWA) ppm (v/v) 1,000 1,1,1,2-Tetrafluoroethane is a non-flammable gas used primarily as a "high-temperature" refrigerant for domestic refrigeration and automobile air conditioners. Compound Structure and Properties. Order 1,2-Dichloro-1,1,2,2-tetrafluoroethane (Freon #114) as Catalog No. Mixtures with air of the gas 1,1,1,2-tetrafluoroethane are not flammable at atmospheric pressure and temperatures up to 100 °C (212 °F). 98-200 Sieradz, Poland [26][27] This contributes to most deaths by inhalant abuse. US3261748A US383502A US38350264A US3261748A US 3261748 A US3261748 A US 3261748A US 383502 A US383502 A US 383502A US 38350264 A US38350264 A US 38350264A US 3261748 A US3261748 A US 3261748A Authority US United States Prior art keywords 1,1,1,2-Tetrafluoroethane is also being considered as an alternative to sulfur hexafluoride as a dielectric gas. The gas is often mixed with a silicone-based lubricant. These devices began using 1,1,1,2-tetrafluoroethane in the early 1990s as a replacement for the more environmentally harmful R-12. However, mixtures with high concentrations of air at elevated pressure and/or temperature can be ignited. Subchronic and chronic studies were carried out in the rat and a developmental toxicity study in the rabbit with exposures to 1,1,1,2-tetrafluoroethane (HFC 134a) by inhalation. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. The tumors, which were also seen in control animals, were benign and not life-threatening. FUNDAMENTAL AND APPLIED TOXICOLOGY 32, 11-22 (1996) ARTICLE NO. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. At lower concentrations or brief exposure, freons may cause transient eye, nose, and throat irritation. With exposure to pregnant rabbits, the only treatment-related effects were of minimal maternal toxicity at high exposure concentrations; there were no effects on fetal development. Media in category "1,1,1,2-tetrafluoroethane" The following 14 files are in this category, out of 14 total. [19] During the time that it was active, this Wisconsin-specific ban contained loopholes. 1,1,1,2-tetrafluoroethane health effects subchronic toxicity mammals dogs: ntis/ots0543258. 1,1,1,2-Tetrafluoroethane can also be used as a solvent and medical propellant for a wide range of applications. We use cookies to help provide and enhance our service and tailor content and ads. Aerosol cans containing 1,1,1,2-tetrafluoroethane, when inverted, become effective freeze sprays. 1 1,1,1,2-Tetrafluoroethane; CASRN 811-97-2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . It is identified as a potential refrigerant used in place of chlorofluorocarbons. It is a structural analogue of halothane and similarities in the metabolic pathways and liver toxicity of both compounds have been described. M-REF-10. Belongs to … 1,1,1,2-Tetrafluoroethane (also known as norflurane (INN), R-134a, Freon 134a, Forane 134a, Genetron 134a, Florasol 134a, Suva 134a, or HFC-134a) is a hydrofluorocarbon (HFC) and haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential and a lower 100-year global warming potential (1,430, compared to R-12's GWP of 10,900). bronchodilators), wine cork removers, gas dusters ("canned air"), and in air driers for removing the moisture from compressed air. [7] For example, it was legal for a person to purchase gas duster containers with any amount of the chemical because in that instance the chemical is neither intended to be a refrigerant [19] nor is HFC-134a included in the § 7671a listing of class I and class II substances. Order 1,2-Dichloro-1,1,2,2-tetrafluoroethane (Freon #114) as Catalog No. Lifetimes, radiative efficiencies and direct (except for CH4) GWPs relative to CO2", "Refrigerant Transition & Environmental Impacts", "Hydrogenation in supercritical 1,1,1,2 tetrafluoroethane (HFC 134a)", STUDY OF GLASS RESISTIVE PLATE CHAMBERS (RPC) AND CALCULATION OF EFFICIENCY, RPC operation at the LHC experiments in an optimized closed loop gas system, Magnesium recycling in the United States in 1998, Gaseous dielectrics with low global warming potentials – US Patent Application 20080135817 Description, "Changes in Atmospheric Constituents and in Radiative Forcing. Malley LA(1), Carakostas M, Elliott GS, Alvarez L, Schroeder RE, Frame SR, Van Pelt C, Trochimowicz HJ, Rusch GM. Developmental Toxicity and Genotoxicity Studies of 1,1,1,3,3,3-Hexachloropropane (HCC-230fa) in Rats Subchronic Toxicity and Teratogenicity of 2-Chloro-1,1,1,2-tetrafluoroethane (HCFC-124) Toxicological Sciences , Jul 1996 In the rat repeated exposure to 50,000 ppm HFC 134a for 13, 52, and 104 weeks elicited no effect on clinical condition, growth, and survival, or on a variety of hematological, clinical chemistry, and urinary parameters. Occupational exposure to 1,1,1,2-tetrafluoroethane may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1,2-tetrafluoroethane is produced or used. Physical Properties HCF-134a Boiling Point at 1 atm (101.3 kPa or 1.013 bar) Ethylbenzene: Hamster ovary - Result: negative 1,1,1,2-Tetrafluoroethane is a colorless gas with a slight ethereal odor. SUMMARY AND CONCLUSIONS 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC-124 a), a non-flammable colourless gas at room temperature, is used as a replacement for the fully halogenated chlorofluorocarbons 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) has been developed as a substitute for ozone-depleting chlorofluorocarbons (CFCs). [29], Except where otherwise noted, data are given for materials in their, M. Capeans, I. Glushkov, R. Guida, F. Hahn, S. Haider (CERN, Switzerland), Global Warming Potentials of ODS Substitutes Ozone Layer Protection US EPA, "Table 2.14 (Errata). It is included in the IPCC list of greenhouse gases. knowledge on candidate chemicals and formulated test pro-grams to provide a thorough toxicological assessment to modern standards. Other common uses include plastic foam blowing, as a cleaning solvent, a propellant for the delivery of pharmaceuticals (e.g. [28] It is considered safe for this use. A) Freons are very toxic when inhaled in high concentrations and/or for extended periods. disodium tetraborate EC no. [2] Its concentration in the atmosphere and contribution to radiative forcing have been growing since its introduction. Subchronic Toxicity and Teratogenicity of 2-Chloro-1,1,1,2-tetrafluoroethane (HCFC-124) Author links open overlay panel Linda A. Malley a Michael Carakostas a Glenn S. Elliott a Louis Alvarez a Raymond E. Schroeder b Steven R. Frame a Carolyn Van Pelt a Henry J. Trochimowicz a G.M. [16][17] By model year 2021, newly manufactured light-duty vehicles in the United States will no longer use R-134a. Supporting study: An acute toxicity test with the analogue substance 1,1,1,2 -tetrafluoroethane on Rainbow trout (Oncorhynchus mykiss) was performed in accordance with the EU Method C.1 (Acute Toxicity for Fish).Fish were exposed for 96 hours to the test substance. Navigate; Linked Data; Dashboard; Tools / Extras; Stats; Share . Published by Elsevier Inc. All rights reserved. z o.o. [23] Contact of 1,1,1,2-tetrafluoroethane with flames or hot surfaces in excess of 250 °C (482 °F) may cause vapor decomposition and the emission of toxic gases including hydrogen fluoride and carbonyl fluoride,[24] however the decomposition temperature has been reported as above 370 °C,. 1.3 Details of the supplier of the safety data sheet: Supplier: ENTALPIA EUROPE Sp. Applications. Subchronic toxicity and teratogenicity of 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124). 25, 271-280. Treatment-related pathological changes were seen only at study termination at 2 years and were confined to increased incidence of Leydig cell hyperplasia and adenoma in male rats exposed to 50,000 ppm. 1,1,1,2-TETRAFLUOROETHANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. PURPOSE: To obtain the subject compound in a high yield by contacting 1,1,1,2- tetrafluorochloroethane with hydrogen in the presence of a palladium catalyst supported by aluminum fluoride or fluorinated alumina in a gas phase of a specified temperature. HFA-134a was delivered directly from cylinders at vapour concentrations of … Acute inhalation toxicity LC50, 4 h, >2,080,000 mg/m3 (1,1,1,2-Tetrafluoroethane) Acute dermal toxicity Not applicable Skin corrosion/irritation Not applicable Serious eye damage/eye irritation Not applicable Respiratory or skin sensitization Guinea … Structure, properties, spectra, suppliers and links for: 1,1,1,2-Tetrafluoroethane, 811-97-2, 29759-38-4, Norflurane. 1,1,2,2-Tetrafluoroethane (HFC-134) is a colorless gas used as a foam expansion agent and heat transfer fluid. Articles of 2-Chloro-1,1,1… Malley LA(1), Carakostas M, Elliott GS, Alvarez L, Schroeder RE, Frame SR, Van Pelt C, Trochimowicz HJ, Rusch GM. [29][30][31] In combination with pentafluoropropane, it is used as a topical vapocoolant spray for numbing boils before curettage. The Society of Automotive Engineers (SAE) has proposed that it be best replaced by a new fluorochemical refrigerant HFO-1234yf (CF3CF=CH2) in automobile air-conditioning systems. R-134a cylinders are colored light blue. Appl. Mixtures with air of the gas 1,1,1,2-tetrafluoroethane are not flammable at atmospheric pressure and temperatures up to 100 °C (212 °F). Supporting: 2, Mentioning: 21 - Subchronic and chronic studies were carried out in the rat and a developmental toxicity study in the rabbit with exposures to 1,1,1,2-tetrafluoroethane (HFC 134a) by inhalation. CAS 811-97-2 REFRIGERANT 134A (HFC-134A) 1,1,1,2-tetrafluoroethane msds toxicity property Other pertinent literature is also presented, but is described in less detail than the key studies. 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1 1 1 2-tetrafluoroethane toxicity 2021